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General dosage systems

One of the strong points of PMME is implantable pharmaceutical formulations. We have the knowledge and experience to design a pharmaceutical dosage system in such a way that the active compound (drug) is administrated to the human body in a proper way. Our expertise with such controlled release systems ranges from direct release systems up to release over several years. Our power is the combination of expertise about materials, processing, formulation design and characterization methods. This gives us the ability to create product opportunities for our customers. We can optimize existing techniques, add new active compounds in currently known dosage systems and we can create new concepts.

Dosage systems we are specialized in:
- Adhesive bandage (dermal dosage system for several days)
- Implants (degradable and non-degradable systems with a release of 2 days to several years)

The above mentioned types of dosage systems we are able to design from scratch. Through the combination of material and process knowledge.
We are capable to find best suited materials, or are able to modify them in order to have the desired release profile for the active compound.
We know the intricacies of the required industrial production processes (e.g. coating, extrusion).
We fully understand the influence of the process settings on the material properties and visa-versa.
Besides our hands-on experience, we also have the theoretical background for understanding release mechanisms. This gives us the ability to do mathematical modelling of both, diffusion of active compounds through a polymer matrix or the kinetics of a degrading system.
All these tools give us the capability to control the release profile of the active compound of the desired dosage system.
We are furthermore, familiar with the do's and don'ts of Good Manufacturing Practise (GMP). This is useful already at the early stages of development, to achieve a much faster GMP implementation of the later production process.
And last but not least, we have an excellent network of partners in analytical and physical method development to evaluate dosage systems under development.